49ers vs. Panthers odds, picks, line, how to watch, live stream: Model reveals 2022 Week 5 NFL predictions

christian mccaffrey

Two NFC teams will clash in Charlotte, N.C., on Sunday as the Carolina Panthers (1-3) host the San Francisco 49ers (2-2) on CBS and Paramount+. Even though just one game separates them in the standings, San Francisco sits atop the NFC West while Carolina ranks third in the NFC South. The Panthers are coming off a 10-point loss to Arizona in which Baker Mayfield had three turnovers. On the other hand, the Niners won on Monday against the Rams as Jimmy Garoppolo had 239 passing yards and a touchdown. You can stream the game in select markets on Paramount+, which you can try free for 30 days with the promo code NFLONCBS.

Kickoff for Panthers vs. 49ers is set for 4:05 p.m. ET. Caesars Sportsbook lists San Francisco as a 6.5-point favorite in the latest 49ers vs. Panthers odds, while the over/under for total points is 40. In select markets, Sunday’s matchup can be seen live on CBS and streamed live on Paramount+ with their must-have Premium plan, which you can try free with the promo code NFLONCBS.

Paramount+ now has levels of membership so you can watch your local NFL on CBS matchups and much more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream, including plenty of sports like SEC on CBS, NFL on CBS, and the PGA Tour, with no ads, on demand and the ability to download episodes for offline viewing. Before the end of October, you can get 30 days completely free with the promo code NFLONCBS, so sign up now here.

How to watch 49ers vs. Panthers

  • Panthers vs. 49ers date: Sunday, Oct. 9
  • Panthers vs. 49ers time: 4:05 p.m. ET
  • Panthers vs. 49ers TV channel: CBS 
  • Panthers vs. 49ers streaming: Paramount+ (30 days free with promo code NFLONCBS)

Week 5 NFL picks for 49ers vs. Panthers

Before tuning into Sunday’s showdown, you need to see the NFL picks from SportsLine’s advanced computer model. The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

For Panthers vs. 49ers, the model is backing the Under. San Francisco’s games are averaging just 29.3 total points, and the 49ers are the first team in 13 years to have each of their first four games finish with fewer than 35 total points.

The 49ers’ conservative style of offense and suffocating defense are big reasons why their games are so low-scoring. And Carolina isn’t the type of team to suddenly buck that trend as Mayfield ranks second-worst in completion percentage and third-worst in passer rating.

The model projects more turnovers than touchdowns for Mayfield, with Christian McCaffrey being the only Panther with more than 53 total yards. San Francisco is averaging just 10 points per game in road contests and, coming off a short week, the model has the Niners coming away with only two touchdowns. The Under (40) is projected to hit with room to spare, as Panthers vs. 49ers goes Under in well over 50% of simulations. You may be able to stream the game here.

How to watch, live stream the NFL on CBS

Now that you know what to pick, get ready to watch your live local NFL on CBS games on Paramount+ on any device you want. Use the code NFLONCBS to get 30 days free. Visit Paramount+ now to stream your live local CBS sporting events, including the NFL, SEC on CBS, and so much more.