Without Marcus Sasser — the first-team All-American, who aggravated a groin injury during a tight first-round win over 16-seed Northern Kentucky — Houston won’t reach the Final Four.
Just advancing to the second week is going to be a struggle against an Auburn team playing 110 miles from home in Birmingham, Ala.
How to watch Auburn vs. Houston
Gametime: 7:10 p.m. Eastern
Live Stream: March Madness Live app, fuboTV, Sling, YouTube TV, Hulu + Live TV
Auburn (+5.5) over Houston
The Cougars could also see limited contributions from third-leading scorer Jamal Shead, who is dealing with a sore knee.
“I’m very concerned,” Houston coach Kelvin Sampson said.
And he should be, with Auburn’s top-30 defense looming in a de facto road game.
Get the lowdown on the Best USA Sports Betting Sites and Apps
The Tigers have covered three of four games against ranked teams this season.