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NFL odds, lines, picks, spreads, best bets, predictions for Week 4, 2021: Model backing Browns, Seahawks

Denver was one of the popular NFL sleepers heading into the season, and the Broncos have lived up to the billing so far. They have come away with a 3-0 record through their first three games, setting up a showdown with Baltimore on Sunday in one of the biggest games of the Week 4 NFL schedule. Baltimore is a one-point favorite in the latest NFL odds at Caesars Sportsbook. Baltimore kicker Justin Tucker hit an NFL-record 66-yard field goal to give his team a last-second win over Detroit last week.

San Francisco is a three-point favorite against Seattle in one of the other Week 4 NFL spreads. Can the 49ers bounce back from a loss to Green Bay? All of the NFL lines are listed below, and before making any Week 4 NFL picks on these games or others, be sure to see the Week 4 NFL predictions from the proven computer model at SportsLine. 

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 4 of the 2021 season on an incredible 123-81 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 4 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 4 NFL predictions

One of the top Week 4 NFL predictions the model recommends: The Seahawks (+3) cover the spread against the 49ers. After winning on the road against the Colts in Week 1, the Seahawks lost in overtime to the Titans at home in Week 2 and lost 30-17 on the road to the Vikings in Week 3.

However, the offense continues to be productive and should be in a position to score with the 49ers in Week 4. Seattle is averaging 389 yards of total offense per game through three weeks, while their 7.4 yards per play so far this season is best in the league. Unfortunately for the Seahawks, the defense ranks last in the NFL in yards allowed, and an inability to get off the field has led to opponents running 70 more offensive plays in 2021.

Seattle has won 13 of its last 15 against San Francisco, including a series sweep in 2020 in which the Seahawks’ defense limited the 49ers to just 138 rushing yards in two games. The model likes the Seahawks to hold the 49ers to under 100 yards rushing again and two force two turnovers, which helps Seattle cover the spread in nearly 60 percent of simulations and even win outright well over 50 percent of the time.

Another one of the top Week 4 NFL picks from the model: The Browns (-2) cover the spread on the road against the Vikings well over 50 percent of the time. Browns head coach Kevin Stefanski was the offensive coordinator for Minnesota before taking his current job, so he will be familiar with the Vikings’ schemes on Sunday. Both teams like to run the ball, but Browns quarterback Baker Mayfield provides a more dynamic threat than his Vikings counterpart, Kirk Cousins.

The Browns also have the superior defense, making multiple upgrades during the offseason. They have a solid pass rush and more depth, giving them an edge on the road. Browns defensive end Myles Garrett is going to be difficult for Minnesota to slow down and Cleveland is coming off a dominant win over Chicago in which it recorded nine sacks.

SportsLine’s model is predicting a big day from Cleveland running back Nick Chubb, who is expected to rush for 90 yards. He is one of the reasons that the Browns are covering in well over 50 percent of simulations. The under is also cashing at a high rate.

How to make Week 4 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 4 NFL schedule, and it’s calling for an undefeated team to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which undefeated team goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and find out.

Week 4 NFL odds, spreads, lines

Sunday, Oct. 3

Washington at Falcons (+1.5, 47.5)

Featured Game | Atlanta Falcons vs. Washington Football Team

Lions at Bears (-3, 41.5)

Featured Game | Chicago Bears vs. Detroit Lions

Titans at Jets (+6, 44.5)

Featured Game | New York Jets vs. Tennessee Titans

Browns at Vikings (+2, 51.5)

Featured Game | Minnesota Vikings vs. Cleveland Browns

Colts at Dolphins (-2, 42.5)

Featured Game | Miami Dolphins vs. Indianapolis Colts

Panthers at Cowboys (-4.5, 51.5)

Featured Game | Dallas Cowboys vs. Carolina Panthers

Giants at Saints (-7, 42)

Featured Game | New Orleans Saints vs. New York Giants

Chiefs at Eagles (+7, 54.5)

Featured Game | Philadelphia Eagles vs. Kansas City Chiefs

Texans at Bills (-17, 47)

Featured Game | Buffalo Bills vs. Houston Texans

Cardinals at Rams (-4, 54.5)

Featured Game | Los Angeles Rams vs. Arizona Cardinals

Seahawks at 49ers (-3, 52)

Featured Game | San Francisco 49ers vs. Seattle Seahawks

Ravens at Broncos (+1, 44)

Featured Game | Denver Broncos vs. Baltimore Ravens

Steelers at Packers (-6.5, 45.5)

Featured Game | Green Bay Packers vs. Pittsburgh Steelers

Buccaneers at Patriots (+7, 49.5)

Featured Game | New England Patriots vs. Tampa Bay Buccaneers

Monday, Oct. 4

Raiders at Chargers (-3, 51.5)

Featured Game | Los Angeles Chargers vs. Las Vegas Raiders

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